17 Aug Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022

We have received inquiries for degassing in relation to Surface Plasmon Resonance (SPR). and most recently for the Nicoya OpenSPR benchtop SPR. I was curious to learn about the system so that we can provide better support. The following paper “Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022” by Rebecca Whelan and Eliza Hanson provides a good overview and provides information on other papers as well. Summarizing from the abstract and paper.

• The Nicoya OpenSPR is a benchtop surface plasmon resonance (SPR) instrument suitable for label-free interaction analysis of various biomolecules
• The instrument supports assays such as affinity/kinetics characterization, concentration analysis, binding assessment, competition studies, and epitope mapping.
• A review article covers 200 peer-reviewed papers published from 2016 to 2022 that use the OpenSPR platform.
• The review highlights the diverse range of biomolecular analytes and interactions investigated and showcases the instrument’s flexibility and utility.
• The OpenSPR has been extensively utilized in research, including cancer therapeutics development and characterization of nanoparticles for SPR sensors.
• The instrument’s usage has rapidly grown over the years, with increasing numbers of papers citing its use.
• Nicoya has introduced a new high-throughput SPR platform called the Alto, which offers simplified sample handling and additional experimental capabilities such as epitope binning and library screening.
•The Alto combines the benefits of the OpenSPR with enhanced features and is expected to contribute to further advancements in benchtop SPR instruments.

Please see the paper here.