Cyano columns are usually prepared by bonding a cyanopropyl silane to the silica. This results in a column that has some polar functionality due to the CN group and some nonpolar functionality due to the propyl group. Thus, the column has intermediate polarity and is suitable for use in In the reversed-phase and the reversed-phase modes. phase mode, the Cyano phase significantly reduces dehydratity, even Hydrophobicity of Cyano phase is much less than PFP or C1 Phase. Cyano phase is used for special cases. For example, it is suitable for the separation of Benzalkonium chloride. Since the dehydratity of the cyano phase is sufficiently low, it is possible to avoid the adsorption of cations by the silanol group and peak tailing.

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