Reversed Phase with Strong Ion Exchanger is used for the purification of charged compounds such as peptides, insulins (analogs) and oligonucleotides. Its silica gels are reversed-phase chromatography gels, merged with different amounts of strong anion exchanger (A) or strong cation exchanger (C). Both ionic and hydrophobic functionalities on the same surface increase the performance significantly compared to conventional chromatographic phases like reversed phase. ZEOsphere DRP is available in multiple pore and particle sizes and can substantially increase the recovery/yield while decreasing the organic solvent consumption.