SunShell SFC

Supercritical Fluid Chromatography (SFC) is an analytical technique used for the separation and analysis of various chemical compounds. It combines the principles of both gas chromatography (GC) and high-performance liquid chromatography (HPLC) by using supercritical fluids as the mobile phase. The supercritical fluid is typically carbon dioxide (CO2) that has been pressurized and heated to a state between its gaseous and liquid phases, resulting in unique properties that enhance separation capabilities.

Chromanik Technologies and Pyvot offer the Sunshell Supercritical Fluid Chromatography (SFC) Coreshell columns.

The differences between SFC 2-EP, SFC Diol, and SFC Silica, along with their ideal application are listed below:

SunShell SFC 2-EP (2-Ethylpyridine): SFC 2-EP is a popular stationary phase used in Supercritical Fluid Chromatography. It consists of a porous, high-purity silica support that is chemically modified with 2-ethyl pyridine. This stationary phase offers excellent selectivity and high efficiency for a wide range of compounds, making it a versatile option in SFC.Applications. SFC 2-EP is particularly suitable for the separation of pharmaceutical compounds, chiral compounds, natural products, and various classes of small molecules. Its robust selectivity makes it an excellent choice for both analytical and preparative SFC applications.

SunShell SFC Diol:  SFC Diol is another commonly used stationary phase in Supercritical Fluid Chromatography. It is composed of high-purity silica support that is chemically bonded with polar diol groups. This stationary phase provides unique selectivity based on hydrogen bonding interactions. Applications: SFC Diol is well-suited for the separation of polar and moderately polar compounds including carbohydrates, nucleosides, organic acids, and other hydrophilic compounds. It is particularly useful in analyzing complex mixtures and food samples, where retention of polar analytes is essential.

SunShell SFC Silica: SFC Silica refers to the unmodified, bare silica stationary phase employed in Supercritical Fluid Chromatography. Unlike SFC 2-EP and SFC Diol, SFC Silica does not undergo any chemical modification, offering a different set of separation characteristics.
Applications: SFC Silica is often used for the separation of non-polar and moderately polar compounds, such as lipids, hydrocarbons, fat-soluble vitamins, and environmental pollutants. It provides excellent peak shape and separation efficiency for these analytes.

In summary, the choice of SFC technology depends on the specific application and the nature of the compounds to be separated. SFC 2-EP offers versatile selectivity and efficiency for pharmaceutical, chiral, and small molecules. SFC Diol provides excellent separation for polar and hydrophilic compounds, including carbohydrates and organic acids. SFC Silica is ideal for the separation of non-polar and moderately polar compounds, such as lipids and hydrocarbons.

By leveraging the unique capabilities of these SFC technologies, scientists and researchers can achieve efficient and reliable separations in a wide range of analytical and preparative applications.