Synthetic adsorbents are a series of products based on ion exchange resin manufacturing technology, and are designed for the uses as solid extractant. Synthetic adsorbents have large surface area and fine pore structures inside the particle like activated carbon. For this porous characteristic, they can effectively adsorb organic compounds from aqueous solutions. Extraction processes with synthetic adsorbents enables reducing solvent amount and safer operations compared with conventional solvent extraction techniques.
A synthetic adsorbent is spherical particle, and inside it, there exist effective fine pore structures suitable for the diffusion of solutes.
Smaller solutes can penetrate into the particle by diffusing through the pores, when a solution is allowed to contact with adsorbent particles.
On the contrary, molecules that are larger than pore size cannot penetrate into the inside of particle. Consequently, such molecules are not adsorbed on synthetic adsorbents (this phenomenon is so-called molecular sieving effect).
Synthetic adsorbents are used for the separation of valuable compounds from plant extracts and fermentation products for pharmaceutical intermediates and food additives.
Synthetic adsorbents are stable in acidic, alkaline solutions and in organic solvents, and they can be easily regenerated under mild conditions for repeated uses.
There are three types of chemical structures for synthetic adsorbents; aromatic, modified aromatic and methacrylic series.
The chemical structure dominates the degree of hydrophobicity of synthetic adsorbents. Hydrophobicity of adsorbent is important in selecting a suitable type of adsorbent according to the chemical nature of target compounds.
|Aromatic||Aromatic type adsorbents are the standard grade and are based on crosslinked polystyrenic matrix. They are widely used in different industrial fields; extraction of antibiotic intermediates from fermentation broth, separation of peptides, or food additives, debittering of citrus juice etc.
DIAION™ HP20 HP21 / SEPABEADS™ SP825L SP850 SP70 SP700
|Modified Aromatic||Modified aromatic type is based on brominated aromatic matrix which gives enhanced hydrophobicity. This type adsrobent is suitable for adsorption of organic substances of very low concentration or of highly hydrophilic substances.
|Methacrylic||Methacrylic type is based on methacrylic ester copolymer, and has relatively hydrophilic nature. This type of adsorbent is suitable for adsorption of polyphenols and surfactants.
Mitsubishi Chemical supplies wide variety of synthetic adsorbents with different pore structures. The most appropriate type of adsorbent can be selected according to the pore size of adsorbent and the molecular size of the target compound (or sometimes unfavorable compounds to be removed).
Another important parameter is surface area of resins. Adsorbent with large surface area shows high uptake capacity, especially for small molecules.
Pore size is an important key parameter which determines the adsorptive characteristics of synthetic adsorbents.
Smaller pore adsorb only small molecules while larger molecules are excluded (molecular sieving effect). On the other hand, larger pores can adsorb large molecules such as proteins.
By selecting appropriate size of pore according to the nature of target substance, it is possible to establish more effective purification processes.
Standard synthetic adsorbents have ca 0.5 mm mean particle diameter. This size is designed for most industrial scale processes.
Smaller particle size adsorbents are used for fine separation/purification applications as reversed-phase chromatographic packing materials.
It is well known that smaller size resins are required to obtain higher purity and better recovery in chromatographic separation of pharmaceuticals. Mitsubishi Chemical offers several types of synthetic adsorbent grades in very useful particle size distributions for industrial scale chromatography.
Mitsubishi chemical also offers analytical HPLC packing media MCI GEL™ which has same chemical and physical structure as these grades. Industrial scaling up of separation process is easily attained by using our product line up.
HP20SS and SP20SS are directly polymerized, small particle size version of HP20. The wide pore polymer matrix provides excellent kinetics and capacity for small biomolecules at both preparative and process scale. They offer nice balance of pressure flow characteristics and true chromatographic fractionation and have also been successfully applied in simulated moving bed (SMB) applications for a variety of small biomolecules. They often compete with bonded silica supports for preparative and industrial applications.
SP207SS is a small size version of modified aromatic type SEPABEADS™ SP207. It is applied to reversed phase chromatography. The brominated polymeric matrix provides unique selectivity, full pH operating range and long operating life versus conventional bonded silica packing materials used in preparative and industrial applications.
|Water Content (%)||55-67||55-65||43-53|
|Particle Size||on 150μm
|Example of Porosity Pore Volume (㎖/g) Specific Surface Area (m2/g) Pore Radius (Å)||1.2
|Operating Temperature (℃)||130 max.||130 max.|
|Chemical structure||Good point||Adsorption Ability|
|Synthetic adsorbent of Styrene body
HP20 / HP20SS / HP21 / SP70 / SP700 / SP825L / SP850 / CHP20 / CHP50
|Synthetic adsorbent of bromated Styrene body
|Synthetic adsorbent of Methacryle ester body
HP2MGL / CMG20
|Particle distribution (0.25mm)||≥90%||≥95%||–||–||≥90% (0.25mm)||≥90% (0.25mm)||≥90% (≥300mm)|
|Effective size (mm)||≥0.25||–||–||≥0.25||≥0.25||≥0.30|
|Mean diameter (mm)||–||–||0.45||0.45||–||–||–||–|
|Surface area (m2/g) (m2/mL)||930
|Pore volume (ml/g)||1.1||1.4||1.5||2.2||1.3||1.3||1.0||1.3|
|Mode radius (Angstrom)||45||70||70||90||110||290||110||240|
|Cephalosporin C adsorption weight (g/L)||85||76||60||76||48||38||119||<10|
Note: pre-distribution and CPC adsorption weight is a reference value
|MCI™ GEL 3-10μm||MCI™ GEL 10-50μm||DIAION™ SEPABEADS™ 50-250μm||DIAION™ SEPABEADS™ ＞250μm|
|Organic compound||CHP20 / C04
CMG20 / C04
|CHP20 / P30
CHP50 / P30
CMG20 / P30
|SP20SS / HP20SS||HP21
|Sugar and Amino acid||CK Series