Synthetic Adsorbents

DIAION™ & SEPABEADS™ Synthetic Adsorbents

GENERAL FEATURES

Synthetic adsorbents are a series of products based on ion exchange resin manufacturing technology, and are designed for the uses as solid extractant. Synthetic adsorbents have large surface area and fine pore structures inside the particle like activated carbon. For this porous characteristic, they can effectively adsorb organic compounds from aqueous solutions. Extraction processes with synthetic adsorbents enables reducing solvent amount and safer operations compared with conventional solvent extraction techniques.

PROPERTIES

A synthetic adsorbent is spherical particle, and inside it, there exist effective fine pore structures suitable for the diffusion of solutes.

Smaller solutes can penetrate into the particle by diffusing through the pores, when a solution is allowed to contact with adsorbent particles.

On the contrary, molecules that are larger than pore size cannot penetrate into the inside of particle. Consequently, such molecules are not adsorbed on synthetic adsorbents (this phenomenon is so-called molecular sieving effect).

APPLICATION FIELDS

Synthetic adsorbents are used for the separation of valuable compounds from plant extracts and fermentation products for pharmaceutical intermediates and food additives.

STABILITY

Synthetic adsorbents are stable in acidic, alkaline solutions and in organic solvents, and they can be easily regenerated under mild conditions for repeated uses.

TECHNICAL MANUAL

TYPES OF SYNTHETIC ADSORBENTS AND SELECTION GUIDE CHEMICAL STRUCTURE

There are three types of chemical structures for synthetic adsorbents; aromatic, modified aromatic and methacrylic series.

Mitsubishi’s_Synthetic_Adsorbents_List

The chemical structure dominates the degree of hydrophobicity of synthetic adsorbents. Hydrophobicity of adsorbent is important in selecting a suitable type of adsorbent according to the chemical nature of target compounds.

Aromatic Aromatic type adsorbents are the standard grade and are based on crosslinked polystyrenic matrix. They are widely used in different industrial fields; extraction of antibiotic intermediates from fermentation broth, separation of peptides, or food additives, debittering of citrus juice etc.
DIAION™ HP20 HP21 / SEPABEADS™ SP825L SP850 SP70 SP700
Modified Aromatic Modified aromatic type is based on brominated aromatic matrix which gives enhanced hydrophobicity. This type adsrobent is suitable for adsorption of organic substances of very low concentration or of highly hydrophilic substances.
SEPABEADS™ SP207
Methacrylic Methacrylic type is based on methacrylic ester copolymer, and has relatively hydrophilic nature. This type of adsorbent is suitable for adsorption of polyphenols and surfactants.
DIAION™ HP2MGL

PORE STRUCTURE

Mitsubishi Chemical supplies wide variety of synthetic adsorbents with different pore structures. The most appropriate type of adsorbent can be selected according to the pore size of adsorbent and the molecular size of the target compound (or sometimes unfavorable compounds to be removed).

Another important parameter is surface area of resins. Adsorbent with large surface area shows high uptake capacity, especially for small molecules.

PORE SIZE DISTRIBUTION OF SYNTHETIC ADSORBENTS

Pore size is an important key parameter which determines the adsorptive characteristics of synthetic adsorbents.

Smaller pore adsorb only small molecules while larger molecules are excluded (molecular sieving effect). On the other hand, larger pores can adsorb large molecules such as proteins.

By selecting appropriate size of pore according to the nature of target substance, it is possible to establish more effective purification processes.


PARTICLE SIZE

Standard synthetic adsorbents have ca 0.5 mm mean particle diameter. This size is designed for most industrial scale processes.

SMALLER PARTICLE-SIZE ADSORBENTS

Smaller particle size adsorbents are used for fine separation/purification applications as reversed-phase chromatographic packing materials.

Synthetic Resins of Small Particle \-size for Chromatographical Separation

It is well known that smaller size resins are required to obtain higher purity and better recovery in chromatographic separation of pharmaceuticals. Mitsubishi Chemical offers several types of synthetic adsorbent grades in very useful particle size distributions for industrial scale chromatography.

Mitsubishi chemical also offers analytical HPLC packing media MCI GEL™ which has same chemical and physical structure as these grades. Industrial scaling up of separation process is easily attained by using our product line up.

Aromatic Type DIAION™ HP20SS, SEPABEADS™ SP20SS

HP20SS and SP20SS are directly polymerized, small particle size version of HP20. The wide pore polymer matrix provides excellent kinetics and capacity for small biomolecules at both preparative and process scale. They offer nice balance of pressure flow characteristics and true chromatographic fractionation and have also been successfully applied in simulated moving bed (SMB) applications for a variety of small biomolecules. They often compete with bonded silica supports for preparative and industrial applications.

Modified Aromatic Type SEPABEADS™ SP207SS

SP207SS is a small size version of modified aromatic type SEPABEADS™ SP207. It is applied to reversed phase chromatography. The brominated polymeric matrix provides unique selectivity, full pH operating range and long operating life versus conventional bonded silica packing materials used in preparative and industrial applications.

Grade Name DIAION™
HP20SS
SEPABEADS™
SP20SS
SEPABEADS™
SP207SS
Chemical Structure
Shipping Density
(g/ℓ-R; approx.)
670 660 780
Water Content (%) 55-67 55-65 43-53
Particle Size on 150μm
63-150μm
through 63μm
15% max.
70% min.
20% max.
on 75μm
63-75μm
through 63μm
30% max.
55% min.
15% max.
on 150μm
63-150μm
through 63μm
15% max.
70% min.
20% max.
Example of Porosity Pore Volume (㎖/g) Specific Surface Area (m2/g) Pore Radius (Å) 1.2
560
290
1.0
590
110
Operating Temperature (℃) 130 max. 130 max.


Mitsubishi’s Synthetic adsorbent

Chemical structure Good point Adsorption Ability
Synthetic adsorbent of Styrene body
HP20 / HP20SS / HP21 / SP70 / SP700 / SP825L / SP850 / CHP20 CHP50
  • Standard type
  • Have interaction of π-π bond adsorb materials to have double strongly
strong
Synthetic adsorbent of bromated Styrene body
SP207
  • High hydrophobicity
    Can adsorb low hydrophobic materials
  • High density(1.2)
Very strong
Synthetic adsorbent of Methacryle ester body
HP2MGL / CMG20
  • Have ability of hydrogen bond can adsorb high hydrophilic material
    for example carboxylic compound, ester compound amino, amid compound
  • it is possible to be chromatography with normal phase
Hydrophobic weak
Hydrophilic strong

Mitsubishi’s Synthetic adsorbents list

Name SP850 SP825L SP70 SP700 HP21 HP20 SP207 HP2MGL
Water content 46-52% 52-62% 55-65% 60-70% 45-55% 55-65% 43-53% 55-65%
Particle distribution (0.25mm) ≥90% ≥95% ≥90% (0.25mm) ≥90% (0.25mm) ≥90% (≥300mm)
Effective size (mm) ≥0.25 ≥0.25 ≥0.25 ≥0.30
Uniformity coefficient ≤1.6 ≤1.6 ≤1.6 ≤1.6
Mean diameter (mm) 0.45 0.45
Surface area (m2/g) (m2/mL) 930
320
930
290
870
220
1200
280
640
190
590
160
600
250
570
150
Pore volume (ml/g) 1.1 1.4 1.5 2.2 1.3 1.3 1.0 1.3
Mode radius (Angstrom) 45 70 70 90 110 290 110 240
Cephalosporin C adsorption weight (g/L) 85 76 60 76 48 38 119 <10

Note: pre-distribution and CPC adsorption weight is a reference value

Scalability

[Key point]

  • Easy to scale up
  • We can offer separation media for all R&D stage.
MCI™ GEL 3-10μm MCI™ GEL 10-50μm DIAION™ SEPABEADS™ 50-250μm DIAION™ SEPABEADS™ >250μm
Organic compound CHP20 / C04
CMG20 / C04
CHP20 / P30
CHP50 / P30
CMG20 / P30
SP20SS / HP20SS HP21
HP20
HP2MGL
Sugar and Amino acid CK Series
CA Series
CK Series
CA Series
UBK Series
UMA Series
SK Series
SA Series
Protein XtalSpeed™
CQA Series
CQK Series
MabSpeed™
ChromSpeed™
FP-DA13

https://pyvot.tech/synthetic-adsorbents/small-particle-size-adsorbents/